Dzongsar Khyentse Rinpoche received teachings from many of the greatest contemporary masters of Tibetan Buddhism, including the 16th Karmapa, Chatral Rinpoche, Nyoshul Khen Rinpoche, Khenpo Appey, and his grandfathers, Dudjom Rinpoche and Lama Sonam Zangpo. His root guru was Dilgo Khyentse Rinpoche, who began training Rinpoche from the age of seven.
While still a teenager, Rinpoche built a small retreat center in Ghezing, Sikkim, and soon began traveling and teaching around the world. In the 1980s, he began the restoration of Dzongsar Monastery in Derge, the responsibility for which he had inherited from his previous incarnation, Khyentse Chökyi Lodrö. He established Dzongsar Institute in Chauntra, which has grown to be one of the most respected institutions for advanced dialectical study in India. He also oversees two monasteries in Bhutan, and has established dharma centres in Australia, Europe, North America, and Asia. He has written several books and has conceived, written and directed award-winning films. Rinpoche constantly travels all over the world, practicing and teaching the Dharma.